Phb2 Gene Summary [Mouse]
Enables sphingolipid binding activity. Involved in several processes, including positive regulation of non-canonical NF-kappaB signal transduction; regulation of cytochrome-c oxidase activity; and regulation of gene expression. Acts upstream of or within several processes, including mammary gland development; negative regulation of intracellular estrogen receptor signaling pathway; and negative regulation of mammary gland epithelial cell proliferation. Located in cell surface; mitochondrial inner membrane; and nucleus. Part of mitochondrial prohibitin complex. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; nose; and respiratory system. Orthologous to human PHB2 (prohibitin 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Phb2 |
| Official Name | prohibitin 2 [Source:MGI Symbol;Acc:MGI:102520] |
| Ensembl ID | ENSMUSG00000004264 |
| Bio databases IDs | |
| Aliases | prohibitin 2 |
| Synonyms | BAP, Bap-37, Bcap27, BCAP37, BCR ASSOCIATED protein37, hBAP, p22, PNAS-141, PROHIBITIN 2, REA, TERP1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Phb2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- sphingolipid binding
- dimerization domain
- LXXLL motif
- SPFH_like
- alpha helix
- protein binding
- identical protein binding
- binding protein
- prohibitin homologues
- HflC protein
- protein homodimerization
- SPFH domain / Band 7 family
- tyrosine phosphorylation site
- protein heterodimerization
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- weight gain
- colorectal cancer
- liver damage
- hypoglycemia
- Alzheimer disease
- gastric cancer
- neuroinflammation
- myocardial dysfunction
- myocardial fibrosis
role in cell
- phosphorylation in
- apoptosis
- expression in
- proliferation
- differentiation
- migration
- tubulation
- activation
- cell viability
- quantity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- glutaminergic synapse
- cell surface
- cell periphery
- cellular membrane
- Nucleus
- Plasma Membrane
- Mitochondria
- lipid droplets
- mitochondrial membrane
- mitochondrial nucleoids
- mitochondrial outer membrane
- mitochondrial inner membrane
- inner nuclear membrane
- nuclear matrix
- synapse
- membrane rafts
- axons
- postsynaptic density
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Phb2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of branching involved in mammary gland duct morphogenesis
- B cell activation
- positive regulation of sequence-specific DNA binding transcription factor activity
- mammary gland branching involved in thelarche
- regulation of cardiolipin metabolic process
- positive regulation of exit from mitosis
- regulation of complement activation
- mammary gland alveolus development
- negative regulation of transcription, DNA-dependent
- positive regulation of immunoglobulin production
- mammary gland epithelial cell proliferation
- cellular response to hypoxia
- cell migration
- intracellular estrogen receptor signaling pathway
- sister chromatid cohesion
- negative regulation of sequence-specific DNA binding transcription factor activity
- positive regulation of MAPK cascade
- macromitophagy
- mitochondrion organization
- CD40 signaling pathway
- cellular response to retinoic acid
- negative regulation of apoptotic process
- protein import into nucleus
- positive regulation of ERK1 and ERK2 cascade
- RIG-I signaling pathway
- negative regulation of intracellular estrogen receptor signaling pathway
- protein stabilization
- negative regulation of mammary gland epithelial cell proliferation
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
- mitochondrial outer membrane
- plasma membrane
- mitochondrial inner membrane
- cell surface
- nucleus
- presynaptic active zone
- cytoplasm
- mitochondrion
- nuclear matrix
- macromolecular complex
- mitochondrial prohibitin complex
- axon
- cell periphery
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein homodimerization activity
- protein binding
- protein heterodimerization activity
- estrogen receptor binding
- amide binding
- sphingolipid binding