Gbp2b Gene Summary [Mouse]
Enables GMP binding activity and GTPase activity. Involved in cytolysis in another organism; positive regulation of defense response; and response to bacterium. Acts upstream of or within adhesion of symbiont to host; cellular response to interferon-beta; and defense response to other organism. Located in cytoplasmic vesicle and symbiont-containing vacuole membrane. Orthologous to several human genes including GBP2 (guanylate binding protein 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gbp2b |
| Official Name | guanylate binding protein 2b [Source:MGI Symbol;Acc:MGI:95666] |
| Ensembl ID | ENSMUSG00000040264 |
| Bio databases IDs | |
| Aliases | guanylate binding protein 2b |
| Synonyms | Gbp-1, guanylate binding protein 2b, Ifn-induced guanylate binding protein 1, LIMIT, Mag-1, Mpa-1 |
| Species | Mouse, Mus musculus |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gbp2b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- guanosine-diphosphatase
- cytokine binding
- heat shock protein binding
- small monomeric GTPase
- GTPase
- spectrin binding
- enzyme binding
- enzyme
- protein binding
- identical protein binding
- lipopolysaccharide binding
- Guanylate-binding protein, C-terminal domain
- GTP binding
- GMP binding
- endopeptidase inhibitor
- Guanylate-binding protein, N-terminal domain
- GDP binding
- actin binding
- ClassIIa_HDAC_Gln-rich-N
- protein homodimerization
- P-loop containing Nucleoside Triphosphate Hydrolases
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- actin cytoskeleton
- Nucleus
- Plasma Membrane
- Golgi Apparatus
- cytosol
- vesicle membrane
- Golgi membrane
- nucleoplasm
- cytoplasmic vesicles