Arhgap9 Gene Summary [Mouse]
Predicted to enable GTPase activator activity and phosphatidylinositol-3,4,5-trisphosphate binding activity. Predicted to be involved in small GTPase-mediated signal transduction. Predicted to be active in cytoplasm and plasma membrane. Is expressed in thymus primordium. Orthologous to human ARHGAP9 (Rho GTPase activating protein 9). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Arhgap9 |
| Official Name | Rho GTPase activating protein 9 [Source:MGI Symbol;Acc:MGI:2143764] |
| Ensembl ID | ENSMUSG00000040345 |
| Bio databases IDs | |
| Aliases | Rho GTPase activating protein 9 |
| Synonyms | 10C, AU043488, RGL1, RHO-GTPASE-ACTIVATING, Rho GTPase activating protein 9 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Arhgap9 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RhoGAP domain
- phosphatidylinositol-3,4,5-triphosphate binding
- WW
- PH domain
- GTPase activator
- protein binding
- Pleckstrin homology-like domain
- GTPase-activator protein for Rho-like GTPases
- RhoGAP
- Src Homology 3 domain superfamily
Pathways
Biological processes and signaling networks where the Arhgap9 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- organismal death
- non-small cell lung cancer
- renal clear cell adenocarcinoma
- renal clear cell cancer
- diabetic nephropathy
- autosomal recessive spastic paraplegia type 70
regulates
- RAC
role in cell
- proliferation
- cell viability
- migration
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- secretory granule lumen
- Extracellular Space
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Arhgap9 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of small GTPase mediated signal transduction
- signal transduction
- regulation of GTPase activity
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
- secretory granule lumen
- extracellular region
Molecular Function
What the gene product does at the molecular level
- phosphatidylinositol-3,4,5-trisphosphate binding
- protein binding
- GTPase activator activity