Gata5 Gene Summary [Mouse]
Enables DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including heart development; positive regulation of Notch signaling pathway; and regulation of gene expression. Acts upstream of or within cellular response to BMP stimulus and positive regulation of DNA-templated transcription. Located in chromatin. Is expressed in several structures, including branchial arch; genitourinary system; gut; heart; and respiratory system. Used to study essential hypertension. Human ortholog(s) of this gene implicated in artery disease (multiple); atrial fibrillation (multiple); congenital heart disease (multiple); and dilated cardiomyopathy. Orthologous to human GATA5 (GATA binding protein 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gata5 |
| Official Name | GATA binding protein 5 [Source:MGI Symbol;Acc:MGI:109497] |
| Ensembl ID | ENSMUSG00000015627 |
| Bio databases IDs | |
| Aliases | GATA binding protein 5 |
| Synonyms | bB379O24.1, CHTD5, GATA binding protein 5, GATAS |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gata5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- activation domain
- transcription regulator
- nucleic acid binding
- protein binding
- GATA-type transcription activator, N-terminal
- sequence-specific DNA binding
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- double-stranded DNA binding
- zinc finger binding to DNA consensus sequence [AT]GATA[AG]
- zinc finger domain
- basic domain
- transcription factor activity
- ZnF_GATA
Pathways
Biological processes and signaling networks where the Gata5 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- proteinuria
- hypertension
- prostate cancer
- multiple types congenital heart defects type 5
- chronic obstructive pulmonary disease
- bicuspid aortic valve
- perivascular fibrosis
- glomerulosclerosis
- benign prostatic hyperplasia
- lower urinary tract symptom
role in cell
- phosphorylation in
- expression in
- cell viability
- proliferation
- activation in
- migration
- apoptosis
- invasion by
- transactivation in
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gata5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- intestinal epithelial cell differentiation
- aortic valve morphogenesis
- endocardial cushion fusion
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of Notch signaling pathway
- cardiac muscle tissue development
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of gene expression
- heart induction
- negative regulation of cardiac muscle hypertrophy
- cellular response to BMP stimulus
- positive regulation of gene expression
- cell fate commitment
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- sequence-specific DNA binding transcription factor activity
- zinc ion binding
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- transcription regulatory region sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity