Gtpbp4 Gene Summary [Mouse]
Predicted to enable several functions, including GTP binding activity; GTPase activity; and preribosome binding activity. Acts upstream of or within maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Predicted to be located in cytosol; nucleus; and perinuclear region of cytoplasm. Predicted to be active in nucleolus. Orthologous to human GTPBP4 (GTP binding protein 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gtpbp4 |
| Official Name | GTP binding protein 4 [Source:MGI Symbol;Acc:MGI:1916487] |
| Ensembl ID | ENSMUSG00000021149 |
| Bio databases IDs | |
| Aliases | GTP binding protein 4 |
| Synonyms | 2610028C09Rik, CRFG, GTPB4, GTP binding protein 4, Gtpbp3, LOC683324, LOC689822, NGB, NOG1, RGD1563564 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gtpbp4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ferrous iron transport protein B
- Nucleolar GTP-binding protein 1 (NOG1)
- 50S ribosome-binding GTPase
- GTPase
- enzyme
- protein binding
- GTP binding
- small GTP-binding protein domain
- NOGCT (NUC087) domain
- NOG1 N-terminal helical domain
- ribonucleoprotein binding
- Rab subfamily of small GTPases
- Ras of Complex, Roc, domain of DAPkinase
- P-loop containing Nucleoside Triphosphate Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- chronic kidney disease
- streptozotocin-induced diabetic nephropathy
- colorectal cancer
regulated by
- triamterene
- phenylbutazone
- gentamicin C
- CD3 (complex)
- CD28
- fenamic acid
- indomethacin
- phenacetin
- nitrofurantoin
- cisplatin
role in cell
- growth
- activation in
- migration
- aggregation
- proliferation
- cell viability
- accumulation in
- processing in
- function in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- perinuclear region
- cytosol
- chromosome
- nucleoplasm
- nucleoli
- nuclear envelope
- nuclear scaffolds
- paraspeckle-like structures
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gtpbp4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
- negative regulation of collagen binding
- negative regulation of cell proliferation
- negative regulation of cell-cell adhesion
- ribosomal large subunit biogenesis
- osteoblast differentiation
- negative regulation of DNA replication
- negative regulation of protein ubiquitination
- protein stabilization
- negative regulation of cell migration
- regulation of cyclin-dependent protein kinase activity
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear membrane
- perinuclear region of cytoplasm
- cytoplasm
- membrane
- cytosol
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- GTP binding
- RNA binding
- protein binding
- GTPase activity