Cfl2 Gene Summary [Mouse]
Enables actin filament binding activity. Involved in actin filament fragmentation and skeletal muscle tissue development. Acts upstream of or within actin filament organization; muscle cell cellular homeostasis; and sarcomere organization. Predicted to be located in Z disc. Predicted to be active in actin cytoskeleton and cytoplasm. Is expressed in several structures, including heart; musculature; myotome; neural retinal epithelium; and testis. Human ortholog(s) of this gene implicated in nemaline myopathy 7. Orthologous to human CFL2 (cofilin 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Cfl2 |
| Official Name | cofilin 2, muscle [Source:MGI Symbol;Acc:MGI:101763] |
| Ensembl ID | ENSMUSG00000062929 |
| Bio databases IDs | |
| Aliases | cofilin 2, muscle |
| Synonyms | Cfl2 predicted, cofilin 2, cofilin 2, muscle, NEM7 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cfl2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- actin filament binding
- Cofilin/tropomyosin-type actin-binding protein
- Actin depolymerization factor/cofilin- and gelsolin-like domains
- protein binding
Pathways
Biological processes and signaling networks where the Cfl2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Actin Cytoskeleton Signaling
- Axonal Guidance Signaling
- B Cell Receptor Signaling
- CCR3 Signaling in Eosinophils
- Cdc42 Signaling
- Ephrin A Signaling
- Ephrin B Signaling
- Ephrin Receptor Signaling
- Epithelial Adherens Junction Signaling
- Estrogen Receptor Signaling
- ILK Signaling
- Natural Killer Cell Signaling
- PAK Signaling
- Phagosome Formation
- Rac Signaling
- RhoA Signaling
- RhoGDI Signaling
- Role of Tissue Factor in Cancer
- Semaphorin Signaling in Neurons
- Signaling by Rho Family GTPases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- nemaline myopathy type 7
- muscle weakness
- centronuclear myopathy
- growth failure
role in cell
- quantity
- abnormal morphology
- degeneration
- organization
- homeostasis
- depolymerization
- turnover
- fragmentation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- Nucleus
- I band
- Z line
- pseudopodia
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cfl2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- muscle cell homeostasis
- actin filament severing
- positive regulation of actin filament depolymerization
- skeletal muscle tissue development
- actin filament depolymerization
- sarcomere organization
- actin filament fragmentation
Cellular Component
Where in the cell the gene product is active
- Z disc
- extracellular space
- extracellular vesicular exosome
- cytoplasm
- actin cytoskeleton
- nuclear matrix
- I band
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- protein binding