Dxo Gene Summary [Mouse]
Enables several functions, including 5'-3' exonuclease activity; hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides; and magnesium ion binding activity. Involved in NAD-cap decapping; RNA destabilization; and nuclear mRNA surveillance. Predicted to be located in nucleoplasm and plasma membrane. Predicted to be active in cytosol and nucleus. Orthologous to human DXO (decapping exoribonuclease). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dxo |
| Official Name | decapping exoribonuclease [Source:MGI Symbol;Acc:MGI:1890444] |
| Ensembl ID | ENSMUSG00000040482 |
| Bio databases IDs | |
| Aliases | decapping exoribonuclease |
| Synonyms | decapping exoribonuclease, DOM3L, DOM3Z, NG6, RAI1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dxo often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RAI1 like PD-(D/E)XK nuclease
- 5'-3' exonuclease
- pyrophosphatase
- phosphorous-containing acid anhydride hydrolase
- mRNA binding
- enzyme
- protein binding
- magnesium ion binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Plasma Membrane
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dxo gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- nucleic acid metabolic process
- nuclear-transcribed mRNA catabolic process
- nuclear mRNA surveillance
- RNA destabilization
- mRNA catabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- nucleotide binding
- 5'-3' exonuclease activity
- protein binding
- RNA pyrophosphohydrolase activity
- mRNA binding