Recql5 Gene Summary [Mouse]
Predicted to enable DNA helicase activity; RNA polymerase II complex binding activity; and identical protein binding activity. Acts upstream of or within several processes, including cellular response to camptothecin; negative regulation of double-strand break repair via homologous recombination; and replication-born double-strand break repair via sister chromatid exchange. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of transcription preinitiation complex. Predicted to be active in cytoplasm; nucleus; and replication fork. Orthologous to human RECQL5 (RecQ like helicase 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Recql5 |
| Official Name | RecQ protein-like 5 [Source:MGI Symbol;Acc:MGI:2156841] |
| Ensembl ID | ENSMUSG00000020752 |
| Bio databases IDs | |
| Aliases | RecQ protein-like 5 |
| Synonyms | DKFZP434J0450, RECQ5, Recq5b, Recql5b, RecQ like helicase 5, RecQ protein-like 5 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Recql5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ATP-dependent DNA helicase, RecQ family
- helicase
- DEAD/DEAH box helicase
- helicase superfamily c-terminal domain
- enzyme binding
- enzyme
- protein binding
- identical protein binding
- Helicase conserved C-terminal domain
- DNA helicase
- helicase domain
- RecQ zinc-binding
- Type III restriction enzyme, res subunit
- N-terminal helicase domain of the DEAD-box helicase superfamily
- RecQ helicase protein-like 5 (RecQ5)
- DEAD-like helicases superfamily
- P-loop containing Nucleoside Triphosphate Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- prostate cancer
role in cell
- expression in
- accumulation in
- transcription in
- formation
- stalling
- response by
- stalling in
- formation in
- damage in
- cohesion in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- nucleoplasm
- replication fork
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Recql5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- DNA repair
- negative regulation of transcription elongation from RNA polymerase II promoter
- negative regulation of double-strand break repair via homologous recombination
- DNA replication
- double-strand break repair via homologous recombination
- cellular response to xenobiotic stimulus
- DNA metabolic process
- mitotic cell cycle
- DNA unwinding involved in replication
- chromosome separation
Cellular Component
Where in the cell the gene product is active
- replication fork
- nucleus
- cytoplasm
- cytosol
- chromosome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- DNA binding
- ATP binding
- DNA helicase activity
- metal ion binding
- helicase activity
- four-way junction helicase activity
- 3'-5' DNA helicase activity
- RNA polymerase II core binding
- isomerase activity