Manea Gene Summary [Mouse]
Predicted to enable glycoprotein endo-alpha-1,2-mannosidase activity. Predicted to be located in Golgi apparatus. Predicted to be active in Golgi membrane. Human ortholog(s) of this gene implicated in anxiety disorder; cocaine dependence; and panic disorder. Orthologous to human MANEA (mannosidase endo-alpha). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Manea |
| Official Name | mannosidase, endo-alpha [Source:MGI Symbol;Acc:MGI:2444484] |
| Ensembl ID | ENSMUSG00000040520 |
| Bio databases IDs | |
| Aliases | mannosidase, endo-alpha |
| Synonyms | 4932703L02RIK, ENDO, ENMAN, hEndo, mannosidase endo-alpha, mannosidase, endo-alpha, mannosidase endo-α, mannosidase, endo-α |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Manea often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Glycoside hydrolase families 71, 99, and related domains
- alpha-mannosidase
- enzyme
- glycoprotein endo-alpha-1,2-mannosidase
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Golgi Apparatus
- Golgi membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Manea gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- Golgi apparatus
- Golgi membrane
Molecular Function
What the gene product does at the molecular level
- alpha-mannosidase activity
- glycoprotein endo-alpha-1,2-mannosidase activity