Olfm1 Gene Summary [Mouse]
Involved in neuronal signal transduction and regulation of axon extension. Located in several cellular components, including axonal growth cone; neuronal cell body; and synaptic membrane. Part of AMPA glutamate receptor complex. Is active in glutamatergic synapse. Is extrinsic component of postsynaptic density membrane. Is expressed in several structures, including central nervous system; embryo ectoderm; peripheral nervous system ganglion; sensory organ; and tooth. Orthologous to human OLFM1 (olfactomedin 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Olfm1 |
| Official Name | olfactomedin 1 [Source:MGI Symbol;Acc:MGI:1860437] |
| Ensembl ID | ENSMUSG00000026833 |
| Bio databases IDs | |
| Aliases | olfactomedin 1 |
| Synonyms | AMY, D2Sut1e, NEURONAL OLFACTOMEDIN RELATED ER LOCALIZED, NOE1, Noelin, NOELIN1, NOELIN1-V1, NOELIN1-V4, OlfA, olfactomedin 1, Pancortin, Pancortin3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Olfm1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Olfactomedin-like domain
- Neurogenesis glycoprotein
- Adhesion protein FadA
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metabolic syndrome X
- COVID-19
- schizophrenia
- endometriosis
- psoriasis
- uterine leiomyoma
- leiomyomatosis
- autosomal dominant polycystic kidney disease
role in cell
- apoptosis
- cell death
- extension
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- axon component
- Extracellular Space
- Plasma Membrane
- Endoplasmic Reticulum
- endoplasmic reticulum lumen
- synaptic membrane
- perikaryon
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Olfm1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of epithelial to mesenchymal transition
- negative regulation of gene expression
- regulation of axon extension
- atrioventricular valve formation
- signal transduction
- positive regulation of gene expression
- neuronal signal transduction
- positive regulation of apoptotic process
- nervous system development
- cardiac epithelial to mesenchymal transition
Cellular Component
Where in the cell the gene product is active
- extracellular space
- axonal growth cone
- endoplasmic reticulum
- synapse
- neuronal cell body
- perikaryon
- axon
Molecular Function
What the gene product does at the molecular level
- protein binding