Trhde Gene Summary [Mouse]
Predicted to enable metalloaminopeptidase activity; peptide binding activity; and zinc ion binding activity. Predicted to be involved in peptide catabolic process and proteolysis. Predicted to be active in cytoplasm; extracellular space; and membrane. Is expressed in cerebral cortex and hippocampus region. Orthologous to human TRHDE (thyrotropin releasing hormone degrading enzyme). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Trhde |
| Official Name | TRH-degrading enzyme [Source:MGI Symbol;Acc:MGI:2384311] |
| Ensembl ID | ENSMUSG00000050663 |
| Bio databases IDs | |
| Aliases | TRH-degrading enzyme |
| Synonyms | 9330155P21Rik, PAP-II, PGPEP2, Ppii, thyrotropin-releasing hormone degrading enzyme, TRH-degrading ectoenzyme, TRH-degrading enzyme |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Trhde often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Peptidase M1 N-terminal domain
- Peptidase family M1 domain
- ERAP1-like C-terminal domain
- peptidase
- aminopeptidase
- peptidase GluZincin family
- pyroglutamyl-peptidase II
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Trhde gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- peptide catabolic process
- signal transduction
- proteolysis
- cell-cell signaling
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- cytoplasm
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- pyroglutamyl-peptidase activity
- zinc ion binding
- metalloaminopeptidase activity
- peptide binding
- aminopeptidase activity