Rad54l2 Gene Summary [Mouse]
Enables several functions, including ATP binding activity; ATP hydrolysis activity; and transcription coregulator activity. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in nuclear speck. Is expressed in central nervous system; embryo; limb; and neural ectoderm. Orthologous to human RAD54L2 (RAD54 like 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rad54l2 |
| Official Name | RAD54 like 2 (S. cerevisiae) [Source:MGI Symbol;Acc:MGI:1933196] |
| Ensembl ID | ENSMUSG00000040661 |
| Bio databases IDs | |
| Aliases | RAD54 like 2 (S. cerevisiae) |
| Synonyms | ARIP4, D130058C05, G630026H09RIK, HSPC325, LOC102552166, LOC102723610, RAD54 like 2, RAD54 like 2 (S. cerevisiae), RGD1561889, SRISNF2L |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rad54l2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- protein kinase binding
- helicase superfamily c-terminal domain
- SNF2-related domain
- ATP binding
- N-terminal helicase domain of the DEAD-box helicase superfamily
- transcription cofactor
- protein binding
- DEAD-like helicases superfamily
- Helicase conserved C-terminal domain
- ATPase
- P-loop containing Nucleoside Triphosphate Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- epithelial cancer
- renal clear cell adenocarcinoma
- renal clear cell cancer
- lung adenocarcinoma
- lung adenocarcinoma formation
- organismal death
- renal cell cancer
- thyroid carcinoma
- epithelial thyroid cancer
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- XY bodies
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rad54l2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chromatin remodeling
Cellular Component
Where in the cell the gene product is active
- nucleus
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- DNA binding
- protein binding
- helicase activity