Oard1 Gene Summary [Mouse]
Predicted to enable O-acetyl-ADP-ribose deacetylase activity; hydrolase activity, hydrolyzing N-glycosyl compounds; and purine nucleoside binding activity. Predicted to be involved in DNA damage response; peptidyl-glutamate ADP-deribosylation; and purine nucleoside metabolic process. Predicted to be located in nucleolus and site of DNA damage. Predicted to be active in nucleoplasm. Orthologous to human OARD1 (O-acyl-ADP-ribose deacylase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Oard1 |
| Official Name | O-acyl-ADP-ribose deacylase 1 [Source:MGI Symbol;Acc:MGI:2146818] |
| Ensembl ID | ENSMUSG00000040771 |
| Bio databases IDs | |
| Aliases | O-acyl-ADP-ribose deacylase 1 |
| Synonyms | AC166164.3, AW558560, C6orf130, dJ34B21.3, LOC682854, O-acyl-ADP-ribose deacylase 1, RGD1308299, TARG1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Oard1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- macro domain
- carboxylic ester hydrolase
- binding protein
- N-glycosyl glycosylase
- macrodomain superfamily
- enzyme
- protein binding
- deacetylase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- progression free survival
- Alzheimer disease
- gastric carcinoma
- gastric epithelial cancer
- metabolic syndrome X
- vascular disease
regulated by
- TGFB1
- pexidartinib
regulates
- purine nucleoside
role in cell
- DNA damage response
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Oard1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein de-ADP-ribosylation
- purine nucleoside metabolic process
- response to DNA damage stimulus
Cellular Component
Where in the cell the gene product is active
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- purine nucleoside binding
- protein binding