Gpsm1 Gene Summary [Mouse]
Predicted to enable G-protein alpha-subunit binding activity and GDP-dissociation inhibitor activity. Predicted to be involved in several processes, including establishment of mitotic spindle orientation; negative regulation of GTPase activity; and negative regulation of guanyl-nucleotide exchange factor activity. Predicted to be located in plasma membrane. Predicted to be part of protein-containing complex. Predicted to be active in cell cortex. Predicted to colocalize with Golgi membrane and endoplasmic reticulum membrane. Is expressed in several structures, including aorta; genitourinary system; gut; integumental system; and nervous system. Orthologous to human GPSM1 (G protein signaling modulator 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gpsm1 |
| Official Name | G-protein signalling modulator 1 (AGS3-like, C. elegans) [Source:MGI Symbol;Acc:MGI:1915089] |
| Ensembl ID | ENSMUSG00000026930 |
| Bio databases IDs | |
| Aliases | G-protein signalling modulator 1 (AGS3-like, C. elegans) |
| Synonyms | 1810037C22Rik, Ags2, AGS3, G-protein signaling modulator 1, G-protein signalling modulator 1 (AGS3-like, C. elegans) |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gpsm1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein regulatory motif
- GDP-dissociation inhibitor
- Tetratricopeptide repeats
- GoLoco motif
- protein binding
- tetratricopeptide repeat
- G protein I alpha binding domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hepatic steatosis
- coronary artery disease
- non-insulin-dependent diabetes mellitus
- obesity
- diabetes mellitus
- myocardial infarction
- ulcerative colitis
- insulin resistance
- diabetic retinopathy
- high-fat diet-induced obesity
role in cell
- cell death
- expression in
- quantity
- activation in
- phosphorylation in
- survival
- organization
- biogenesis
- chemotaxis
- signaling in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- cellular membrane
- cell cortex
- Plasma Membrane
- Golgi Apparatus
- cytosol
- endoplasmic reticulum membrane
- Golgi membrane
- nucleoplasm
- perikaryon
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gpsm1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of macroautophagy
- establishment of mitotic spindle orientation
- negative regulation of GTPase activity
- nervous system development
- cell differentiation
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- cell cortex
- cytosol
- Golgi membrane
- macromolecular complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- GDP-dissociation inhibitor activity
- G-protein alpha-subunit binding