Sgo1 Gene Summary [Mouse]
Predicted to enable kinase binding activity. Acts upstream of or within centriole-centriole cohesion. Located in kinetochore. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and heart. Human ortholog(s) of this gene implicated in chronic atrial and intestinal dysrhythmia. Orthologous to human SGO1 (shugoshin 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sgo1 |
| Official Name | shugoshin 1 [Source:MGI Symbol;Acc:MGI:1919665] |
| Ensembl ID | ENSMUSG00000023940 |
| Bio databases IDs | |
| Aliases | shugoshin 1 |
| Synonyms | 3300001M08Rik, CAID, IMAGE 4685140, NY-BR-85, SGO, SGOL1, shugoshin 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sgo1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase binding
- Shugoshin N-terminal coiled-coil region
- protein binding
- PXVXL/I motif
- Shugoshin C terminus
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- liver cancer
- epithelial cancer
- metastasis
- androgenic alopecia
- organismal death
- breast carcinoma
- lymphomagenesis
- lung adenocarcinoma formation
- chronic atrial and intestinal dysrhythmia
role in cell
- expression in
- invasion by
- proliferation
- quantity
- migration
- cohesion
- mitosis
- alignment
- cohesion in
- alignment in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- centrosome
- cytosol
- nucleoplasm
- spindle pole
- nuclear speckles
- kinetochores
- centromeres
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sgo1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- attachment of spindle microtubules to kinetochore
- meiotic chromosome segregation
- centriole-centriole cohesion
- chromosome segregation
- mitotic sister chromatid cohesion, centromeric
Cellular Component
Where in the cell the gene product is active
- centrosome
- spindle pole
- condensed chromosome, centromeric region
- cytosol
- kinetochore
- chromosome, centromeric region
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- kinase binding