Tnks Gene Summary [Mouse]
Predicted to enable histone binding activity; pentosyltransferase activity; and zinc ion binding activity. Predicted to be involved in several processes, including positive regulation of canonical Wnt signaling pathway; post-translational protein modification; and regulation of chromosome organization. Predicted to act upstream of or within peptidyl-serine phosphorylation and peptidyl-threonine phosphorylation. Located in cytosol. Is expressed in several structures, including blastocyst; central nervous system; early embryo; neural retina; and oocyte. Orthologous to human TNKS (tankyrase). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tnks |
| Official Name | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase [Source:MGI Symbol;Acc:MGI:1341087] |
| Ensembl ID | ENSMUSG00000031529 |
| Bio databases IDs | |
| Aliases | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase |
| Synonyms | 4930554K12Rik, AC270292.3, ARTD5, D130072O21RIK, mTNKS1, PARP-5a, PARPL, pART5, TANK1, tankyrase, Tankyrase1, Tankyrase I, tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase, TIN1, TINF1, TNKS1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tnks often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone binding
- Ankyrin repeats (many copies)
- NAD ADP-ribosyltransferase
- SAM (Sterile alpha motif )
- SAM domain
- poly ADP ribose polymerase domain
- Poly(ADP-ribose) polymerase catalytic domain
- Ankyrin repeats (3 copies)
- enzyme
- protein binding
- ADP_ribosyl
- Ankyrin repeat
- Sterile alpha motif
- zinc ion binding
- pentosyltransferase
- SAM domain (Sterile alpha motif)
- ankyrin repeats
Pathways
Biological processes and signaling networks where the Tnks gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- hypertension
- stomatitis
- colon epithelial cancer
- endometriosis
- colon carcinoma
- neuroticism
- plasma cell myeloma
role in cell
- apoptosis
- cell viability
- survival
- loss in
- proliferation
- growth
- phosphorylation in
- degradation in
- elongation
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- high-density microsomal fractions
- nuclear fraction
- low-density microsomal fraction
- centrosome
- Golgi Apparatus
- cytosol
- nuclear pores
- nucleoplasm
- nuclear bodies
- spindle pole
- nuclear envelope
- smooth microsomes
- telomeres
- chromatin
- cytoplasmic fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tnks gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mitotic spindle organization
- protein polyubiquitination
- protein transport
- positive regulation of canonical Wnt receptor signaling pathway
- positive regulation of transcription from RNA polymerase II promoter
- cell division
- spindle assembly
- positive regulation of telomerase activity
- protein localization to chromosome, telomeric region
- positive regulation of telomere maintenance via telomerase
- Wnt receptor signaling pathway
- protein poly-ADP-ribosylation
- regulation of telomere maintenance via telomerase
- protein auto-ADP-ribosylation
- peptidyl-serine phosphorylation
- mRNA transport
- peptidyl-threonine phosphorylation
Cellular Component
Where in the cell the gene product is active
- chromosome, telomeric region
- nucleus
- pericentriolar material
- nuclear membrane
- nuclear body
- cytoplasm
- cytosol
- Golgi membrane
- Golgi apparatus
- nucleoplasm
- nuclear pore
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- nucleotidyltransferase activity
- protein binding
- histone binding
- NAD+ ADP-ribosyltransferase activity