Fbxw4 Gene Summary [Mouse]
Acts upstream of or within cartilage development; embryonic digit morphogenesis; and positive regulation of mesenchymal cell proliferation. Predicted to be part of SCF ubiquitin ligase complex. Is expressed in brain; diencephalon roof plate; midbrain ventricular layer; and midbrain-hindbrain junction. Orthologous to human FBXW4 (F-box and WD repeat domain containing 4). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fbxw4 |
| Official Name | F-box and WD-40 domain protein 4 [Source:MGI Symbol;Acc:MGI:1354698] |
| Ensembl ID | ENSMUSG00000040913 |
| Bio databases IDs | |
| Aliases | F-box and WD-40 domain protein 4 |
| Synonyms | DAC, dactylin, dactylyn, F-box and WD-40 domain protein 4, F-box and WD repeat domain containing 4, FBW4, FBWD4, LOC100911855, SHFM3, SHSF3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fbxw4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- F-box domain
- WD40 repeats
- F-box domain superfamily
- F-box-like
- WD domain, G-beta repeat
- WD40
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fbxw4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- embryonic limb morphogenesis
- Wnt receptor signaling pathway
- SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
- ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- ubiquitin ligase complex
- cytosol
- SCF ubiquitin ligase complex
Molecular Function
What the gene product does at the molecular level
- protein binding