Mcm4 Gene Summary [Mouse]
Enables single-stranded DNA binding activity. Contributes to DNA helicase activity. Acts upstream of or within DNA replication. Part of MCM complex. Is expressed in several structures, including brain; future brain; limb; metanephros; and myocardium layer. Human ortholog(s) of this gene implicated in immunodeficiency 54. Orthologous to human MCM4 (minichromosome maintenance complex component 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mcm4 |
| Official Name | minichromosome maintenance complex component 4 [Source:MGI Symbol;Acc:MGI:103199] |
| Ensembl ID | ENSMUSG00000022673 |
| Bio databases IDs | |
| Aliases | minichromosome maintenance complex component 4 |
| Synonyms | 19G, CDC21, CDC21 homolog, CDC54, hCdc21, IMD54, mcdc21, Mcmd4, minichromosome maintenance complex component 4, mKIAA4003, NKCD, NKGCD, P1-CDC21 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mcm4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- MCM P-loop domain
- enzyme
- protein binding
- MCM AAA-lid domain
- DNA helicase
- MCM helicase family
- minichromosome maintenance proteins
- AAA domain (dynein-related subfamily)
- MCM OB domain
- single-stranded DNA binding
- MCM N-terminal domain
- zinc finger domain
- P-loop containing Nucleoside Triphosphate Hydrolases
Pathways
Biological processes and signaling networks where the Mcm4 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- hepatocellular carcinoma
- liver cancer
- epithelial cancer
- organismal death
- natural killer cell and glucocorticoid deficiency with DNA repair defect
- cervical cancer
- hepatitis B virus-related hepatocellular carcinoma
- lung adenocarcinoma
- lung adenocarcinoma formation
role in cell
- proliferation
- quantity
- association
- anaphase
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- chromatin fraction
- cellular membrane
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mcm4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- double-strand break repair via break-induced replication
- regulation of DNA-dependent DNA replication initiation
- DNA strand elongation involved in DNA replication
- DNA replication
- DNA unwinding involved in replication
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromosome, telomeric region
- CMG complex
- membrane
- MCM complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- DNA helicase activity
- protein binding
- single-stranded DNA-dependent ATP-dependent DNA helicase activity
- single-stranded DNA binding