Igsf21 Gene Summary [Mouse]
Involved in synapse maturation and trans-synaptic signaling, modulating synaptic transmission. Located in external side of plasma membrane; inhibitory synapse; and presynaptic membrane. Is active in postsynaptic density membrane. Is expressed in several structures, including brain; ganglia; genitourinary system; hemolymphoid system gland; and retina. Orthologous to human IGSF21 (immunoglobin superfamily member 21). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Igsf21 |
| Official Name | immunoglobulin superfamily, member 21 [Source:MGI Symbol;Acc:MGI:2681842] |
| Ensembl ID | ENSMUSG00000040972 |
| Bio databases IDs | |
| Aliases | immunoglobulin superfamily, member 21 |
| Synonyms | Gm141, immunoglobin superfamily member 21, immunoglobin superfamily, member 21, immunoglobulin superfamily, member 21, LOC684776, LOC690725, RGD1310117 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Igsf21 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- immunoglobulin domain
- Immunoglobulin like
- Immunoglobulin I-set domain
- protein binding
- Immunoglobulin V-set domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- plasma membrane extracellular face
- presynaptic membrane
- synaptic membrane
- synapse
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Igsf21 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- synapse maturation
- heterophilic cell-cell adhesion
- homophilic cell adhesion
Cellular Component
Where in the cell the gene product is active
- inhibitory synapse
- presynaptic membrane
- adherens junction
- postsynaptic membrane
- external side of plasma membrane