Nrep Gene Summary [Mouse]
Acts upstream of or within regulation of transforming growth factor beta receptor signaling pathway. Predicted to be located in cytoplasm. Is expressed in several structures, including lung; nervous system; otocyst; and retina. Orthologous to human NREP (neuronal regeneration related protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nrep |
| Official Name | neuronal regeneration related protein [Source:MGI Symbol;Acc:MGI:99444] |
| Ensembl ID | ENSMUSG00000042834 |
| Bio databases IDs | |
| Aliases | neuronal regeneration related protein |
| Synonyms | C5orf13, D0H4S114, D4S114, Harp, neuronal regeneration related protein, P311, PRO1873, PTZ17, SEZ17 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nrep often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Neuronal protein 3.1 (p311)
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- breast carcinoma
- idiopathic scoliosis
- myopia
- Huntington disease
- chickenpox
- pervasive developmental disorder
- streptozotocin-induced diabetic nephropathy
- asthma
- diverticular disease
role in cell
- migration
- proliferation
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- focal adhesions
- nucleoli
- cell membrane leading edge
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nrep gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of neuron differentiation
- regulation of transforming growth factor beta receptor signaling pathway
- axon regeneration
Cellular Component
Where in the cell the gene product is active
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding