Abhd4 Gene Summary [Mouse]
Enables lysophospholipase activity. Involved in N-acylphosphatidylethanolamine metabolic process. Acts upstream of or within N-acylethanolamine metabolic process. Predicted to be active in lipid droplet and mitochondrion. Is expressed in central nervous system; dorsal root ganglion; genitourinary system; and retina. Orthologous to human ABHD4 (abhydrolase domain containing 4, N-acyl phospholipase B). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Abhd4 |
| Official Name | abhydrolase domain containing 4 [Source:MGI Symbol;Acc:MGI:1915938] |
| Ensembl ID | ENSMUSG00000040997 |
| Bio databases IDs | |
| Aliases | abhydrolase domain containing 4 |
| Synonyms | 1110035H23RIK, ABH4, abhydrolase domain containing 4, abhydrolase domain containing 4, N-acyl phospholipase B |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Abhd4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- alpha/beta hydrolase fold
- lysophospholipase
- alpha/beta hydrolases
- Alpha/beta hydrolase family
- peptidase
- hydrolase
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- organismal death
- preeclampsia
regulates
- lipid
- enzyme
- N-acylphosphatidylethanolamine
- N-acyl-lysophosphatidylethanolamine
- oleic acid
- N-stearoyl-lysophosphatidylethanolamine
- N-acylethanolamine
- N-palmitoyl-lysophosphatidylethanolamine
- 1,2-dihydroxy-sn-glycero-3-phospho(N-palmitoyl)ethanolamine
- N-arachidoyl-lysophosphatidylethanolamine
role in cell
- adipogenesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Abhd4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- N-acylphosphatidylethanolamine metabolic process
- phosphatidylethanolamine acyl-chain remodeling
- lipid homeostasis
- lipid catabolic process
- phosphatidic acid biosynthetic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- lipid particle
- mitochondrion
Molecular Function
What the gene product does at the molecular level
- lysophospholipase activity
- lysophosphatidic acid acyltransferase activity
- protein binding
- hydrolase activity