Plin3 Gene Summary [Mouse]
Predicted to be involved in several processes, including cellular response to glucose starvation; lipid droplet disassembly; and positive regulation of triglyceride storage. Predicted to be located in endosome membrane. Predicted to be active in cytosol and lipid droplet. Is expressed in several structures, including choroid plexus; genitourinary system; gut; nasal septum; and turbinate bone primordium. Orthologous to human PLIN3 (perilipin 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Plin3 |
| Official Name | perilipin 3 [Source:MGI Symbol;Acc:MGI:1914155] |
| Ensembl ID | ENSMUSG00000024197 |
| Bio databases IDs | |
| Aliases | perilipin 3 |
| Synonyms | 1300012C15Rik, AABR07066529.1, CSP, M6PRBP1, perilipin 3, PP17, TIP47 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Plin3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- Perilipin family
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lung carcinoma
- lung carcinoma process
- liver cancer
- epithelial cancer
- hepatocellular carcinoma
- colon cancer
- androgenic alopecia
- hepatic steatosis
- epithelial uterine cancer
- cervical cancer
role in cell
- migration
- growth
- function
- formation
- morphology
- cell death
- size
- response by
- lipolysis in
- depolarization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- endosomal fractions
- lipid droplet surface
- cellular membrane
- Plasma Membrane
- endosomes
- Golgi Apparatus
- Endoplasmic Reticulum
- lipid droplets
- cytosol
- endosomal membrane
- transport vesicles
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Plin3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- lipid storage
- positive regulation of sequestering of triglyceride
- vesicle-mediated transport
- cellular response to glucose starvation
Cellular Component
Where in the cell the gene product is active
- lipid particle
- endosome
- cytoplasm
- membrane
- cytosol
- Golgi apparatus
- endosome membrane
- transport vesicle
Molecular Function
What the gene product does at the molecular level
- protein binding
- cadherin binding