YEATS2 Gene Summary [Human]
Summary: The protein encoded by this gene is a scaffolding subunit of the ATAC complex, which is a complex with acetyltransferase activity on histones H3 and H4. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2017]
Details
| Type | Protein Coding |
| Official Symbol | YEATS2 |
| Official Name | YEATS domain containing 2 [Source:HGNC Symbol;Acc:HGNC:25489] |
| Ensembl ID | ENSG00000163872 |
| Bio databases IDs | |
| Aliases | YEATS domain containing 2 |
| Synonyms | FAME4, mKIAA1197, RGD1566176, YEATS domain containing 2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human YEATS2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone-fold domain
- YEATS domain
- YEATS domain family, chromatin reader proteins
- histone binding
- transcription regulator
- transcription co-repressor
- protein binding activity, bridging
- protein binding
- YEATS family
- TATA-binding protein binding
- prokaryotic YEATS domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulates
- DNA promoter
- DNA endogenous promoter
- Tk
- RNA polymerase II
disease
- epithelial cancer
- prostate cancer
- prostatic carcinoma
- breast cancer
- familial adult myoclonic epilepsy type 4
- toxic epidermal necrolysis
role in cell
- expression in
- cell cycle progression
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- mitotic spindle
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human YEATS2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- regulation of cell division
- chromatin remodeling
- regulation of tubulin deacetylation
- regulation of embryonic development
- regulation of transcription, DNA-dependent
- regulation of cell cycle
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- NuA4 histone acetyltransferase complex
- mitotic spindle
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- histone binding
- transcription corepressor activity
- TBP-class protein binding