Atp1b2 Gene Summary [Mouse]
Predicted to enable several functions, including ATPase binding activity; P-type sodium:potassium-exchanging transporter activity; and protein heterodimerization activity. Involved in cell-substrate adhesion; negative regulation of glial cell migration; and positive regulation of neuron projection development. Acts upstream of or within several processes, including brain development; motor behavior; and photoreceptor cell maintenance. Located in several cellular components, including astrocyte end-foot; cell body membrane; and external side of plasma membrane. Is expressed in several structures, including brain; early conceptus; genitourinary system; retina; and spinal cord. Orthologous to human ATP1B2 (ATPase Na+/K+ transporting subunit beta 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Atp1b2 |
| Official Name | ATPase, Na+/K+ transporting, beta 2 polypeptide [Source:MGI Symbol;Acc:MGI:88109] |
| Ensembl ID | ENSMUSG00000041329 |
| Bio databases IDs | |
| Aliases | ATPase, Na+/K+ transporting, beta 2 polypeptide |
| Synonyms | AMOG, ATPase, Na+/K+ transporting, beta 2 polypeptide, ATPase Na+/K+ transporting subunit beta 2, ATPase Na+/K+ transporting subunit β 2, ATPase, Na+/K+ transporting, β 2 polypeptide, ATPB2, ATPB2S, Na,K-ATPase β subunit 2, RATATPB2S |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Atp1b2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ATPase stimulator
- ATPase binding
- protein binding activity, bridging
- Na+/K+-exchanging ATPase
- protein binding
- Sodium / potassium ATPase beta chain
- protein heterodimerization
- transporter
Pathways
Biological processes and signaling networks where the Atp1b2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- insomnia
- eyelids fail to open
- androgenic alopecia
- paralysis
- esophageal squamous cell carcinoma
- esophageal squamous cell cancer
- tremor
role in cell
- size
- migration by
- abnormal morphology
- development
- repolarization
- maintenance
- degeneration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- Cytoplasm
- cell periphery
- intracellular membranes
- cellular membrane
- sarcoplasmic reticulum
- apical cell surfaces
- basolateral cell surfaces
- microsome
- plasma membrane extracellular face
- apical membrane
- lateral plasma membrane
- synapse
- photoreceptor inner segments
- transverse tubules
- lateral cell-cell contacts
- microsomal membrane
- cellular protrusions
- perikaryon
- astrocyte projections
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Atp1b2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuronal-glial interaction involved in hindbrain glial-mediated radial cell migration
- positive regulation of ATPase activity
- cellular sodium ion homeostasis
- third ventricle development
- membrane repolarization
- retina homeostasis
- cellular potassium ion homeostasis
- lateral ventricle development
- photoreceptor cell maintenance
- positive regulation of neuron projection development
- cell-substrate adhesion
- protein stabilization
- cell communication by electrical coupling involved in cardiac conduction
Cellular Component
Where in the cell the gene product is active
- lateral plasma membrane
- cytoplasm
- cell body membrane
- membrane
- external side of plasma membrane
- sodium:potassium-exchanging ATPase complex
- cell projection membrane
- photoreceptor inner segment
- apical plasma membrane
- plasma membrane
- cell periphery
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein heterodimerization activity
- ATPase activator activity
- protein binding, bridging
- ATPase binding