Slc4a5 Gene Summary [Mouse]
Enables sodium:bicarbonate symporter activity. Acts upstream of or within several processes, including cerebrospinal fluid secretion; mitochondrion distribution; and retina development in camera-type eye. Predicted to be located in apical plasma membrane and basolateral plasma membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including nervous system; retina; and thyroid gland. Orthologous to human SLC4A5 (solute carrier family 4 member 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc4a5 |
| Official Name | solute carrier family 4, sodium bicarbonate cotransporter, member 5 [Source:MGI Symbol;Acc:MGI:2443220] |
| Ensembl ID | ENSMUSG00000068323 |
| Bio databases IDs | |
| Aliases | solute carrier family 4, sodium bicarbonate cotransporter, member 5 |
| Synonyms | C330006M16, C330016K18RIK, NBC4, NBCe2, solute carrier family 4 member 5, solute carrier family 4, sodium bicarbonate cotransporter, member 5 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Slc4a5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- sodium:bicarbonate symporter
- HCO3- transporter family
- Band 3 cytoplasmic domain
- anion exchange protein
- inorganic anion exchanger
- transporter
Pathways
Biological processes and signaling networks where the Slc4a5 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- proteinuria
- Wegener granulomatosis
- post-traumatic stress disorder
- renal tubular acidosis
- developmental delay
- retinal detachment
- visual disturbance
- polyuria
role in cell
- expression in
- development
- loss
- pH
- distribution
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- apical membrane
- basolateral membrane
- nerve ending
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Slc4a5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- inorganic anion transport
- transmembrane transport
- retina development in camera-type eye
- regulation of systemic arterial blood pressure
- epithelial cell development
- renal system process
- regulation of intracellular pH
- mitochondrion distribution
- regulation of gene expression
- sodium ion transmembrane transport
- bicarbonate transport
- cerebrospinal fluid secretion
Cellular Component
Where in the cell the gene product is active
- membrane
- basolateral plasma membrane
- plasma membrane
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- anion transmembrane transporter activity
- sodium:bicarbonate symporter activity
- inorganic anion exchanger activity