Fxyd1 Gene Summary [Mouse]
This gene encodes a member of the FXYD family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The protein encoded by this gene is a plasma membrane substrate for several kinases, including protein kinase A, protein kinase C, NIMA kinase, and myotonic dystrophy kinase. It is thought to form an ion channel or regulate ion channel activity and act as an accessory protein of Na,K-ATPase. Alternatively spliced transcript variants have been described. [provided by RefSeq, Sep 2009]
Details
| Type | Protein Coding |
| Official Symbol | Fxyd1 |
| Official Name | FXYD domain-containing ion transport regulator 1 [Source:MGI Symbol;Acc:MGI:1889273] |
| Ensembl ID | ENSMUSG00000036570 |
| Bio databases IDs | |
| Aliases | FXYD domain-containing ion transport regulator 1 |
| Synonyms | 0610012C17Rik, 1110006M24Rik, FXYD domain-containing ion transport regulator 1, Phospholemman, Pl, PLM, Pml, Tcp-1 gamma subunit, Tcp-1 γ subunit |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fxyd1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- myosin binding
- ATPase binding
- ATP1G1/PLM/MAT8 family
- chloride channel
- ion channel binding
- sodium channel regulator
- protein binding
- phenylalanine-X-tyrosine-aspartate (FXYD) family
- ion channel
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- non-small cell lung cancer
- schizophrenia
- small cell lung cancer
- cardiac hypertrophy
- preeclampsia
- aortic valve calcification
- androgenic alopecia
- uterine serous papillary cancer
role in cell
- inactivation in
- efflux in
- contraction
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- cellular membrane
- intercellular junctions
- apical membrane
- caveolae
- intercalated disks
- sarcolemma
- transverse tubules
- perikaryon
- axons
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fxyd1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- potassium ion transport
- sodium ion transport
- regulation of cardiac muscle cell membrane potential
- muscle contraction
- regulation of sodium ion transmembrane transporter activity
- regulation of heart contraction
- negative regulation of protein glutathionylation
- chloride transport
Cellular Component
Where in the cell the gene product is active
- T-tubule
- caveola
- sarcolemma
- intercalated disc
- sodium:potassium-exchanging ATPase complex
- apical plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- sodium channel regulator activity
- chloride channel activity
- ion channel binding