Atg2b Gene Summary [Mouse]
Predicted to enable phosphatidylinositol-3-phosphate binding activity and protein-membrane adaptor activity. Predicted to be involved in autophagy of mitochondrion and macroautophagy. Predicted to be located in endoplasmic reticulum membrane; lipid droplet; and phagophore assembly site membrane. Predicted to be active in phagophore and phagophore assembly site. Orthologous to human ATG2B (autophagy related 2B). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Atg2b |
| Official Name | autophagy related 2B [Source:MGI Symbol;Acc:MGI:1923809] |
| Ensembl ID | ENSMUSG00000041341 |
| Bio databases IDs | |
| Aliases | autophagy related 2B |
| Synonyms | 2410024A21RIK, autophagy related 2B, AW558123, BLTP4B, C030004M05RIK, C14orf103, C630028L02Rik, mKIAA4067, RGD1304878 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Atg2b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- lipid transporter
- N-terminal region of Chorein or VPS13
- protein binding
- Autophagy-related protein C terminal domain
- transporter
Pathways
Biological processes and signaling networks where the Atg2b gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- dementia
role in cell
- binding in
- formation
- formation in
- accumulation in
- accumulation
- autophagy in
- autophagic flux in
- frequency
- clustering in
- clustering
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- Endoplasmic Reticulum
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Atg2b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- autophagic vacuole assembly
- piecemeal microautophagy of nucleus
- peroxisome degradation
- mitochondrion degradation
Cellular Component
Where in the cell the gene product is active
- lipid particle
- endoplasmic reticulum membrane
- pre-autophagosomal structure membrane
- pre-autophagosomal structure
Molecular Function
What the gene product does at the molecular level
- protein anchor
- phosphatidylinositol-3-phosphate binding