Npas1 Gene Summary [Mouse]
Enables protein heterodimerization activity. Involved in negative regulation of DNA-templated transcription. Acts upstream of or within maternal behavior; negative regulation of transcription by RNA polymerase II; and startle response. Located in nucleus. Is expressed in several structures, including genitourinary system; limb; lung; and nervous system. Orthologous to human NPAS1 (neuronal PAS domain protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Npas1 |
| Official Name | neuronal PAS domain protein 1 [Source:MGI Symbol;Acc:MGI:109205] |
| Ensembl ID | ENSMUSG00000001988 |
| Bio databases IDs | |
| Aliases | neuronal PAS domain protein 1 |
| Synonyms | bHLHe11, MOP5, neuronal PAS domain protein 1, PASD5 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Npas1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- nuclear export signal
- PAS
- basic Helix Loop Helix (bHLH) domain superfamily
- protein binding
- PAS fold
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription repression domain
- helix loop helix domain
- helix-loop-helix domain
- Helix-loop-helix DNA-binding domain
- transcription factor activity
- protein heterodimerization
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Npas1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- central nervous system development
- negative regulation of transcription, DNA-dependent
- startle response
- maternal behavior
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
Molecular Function
What the gene product does at the molecular level
- sequence-specific DNA binding transcription factor activity
- protein heterodimerization activity
- RNA polymerase II regulatory region sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity