Phf21a Gene Summary [Mouse]
Enables chromatin binding activity. Acts upstream of or within suckling behavior. Predicted to be part of DNA repair complex and histone deacetylase complex. Is expressed in several structures, including central nervous system; cranium; early conceptus; genitourinary system; and hemolymphoid system. Orthologous to human PHF21A (PHD finger protein 21A). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Retained Intron |
| Official Symbol | Phf21a |
| Official Name | PHD finger protein 21A [Source:MGI Symbol;Acc:MGI:2384756] |
| Ensembl ID | ENSMUSG00000058318 |
| Bio databases IDs | |
| Aliases | PHD finger protein 21A |
| Synonyms | Bhc, BHC80, BHC80a, BM-006, D030065N23Rik, IDDBCS, mBHC80, NEDMS, PFTF1, PHD finger protein 21A, RGD1560612 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Phf21a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PHD zinc finger
- protein kinase C conserved region 1 (C1 domain) superfamily
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- PHD finger superfamily
- chromatin binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- abdominal cancer
- cancer
- mental retardation
- hereditary disorder
- schizophrenia
- intellectual developmental disorder with behavioral abnormalities and craniofacial dysmorphism without seizures
- insomnia
- uterine cancer
- female genital tract cancer
- soft tissue sarcoma cancer
role in cell
- expression in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Phf21a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- chromatin organization
Cellular Component
Where in the cell the gene product is active
- histone deacetylase complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- metal ion binding
- chromatin binding