Prelp Gene Summary [Mouse]
Predicted to enable heparin binding activity. Acts upstream of or within cellular senescence. Located in collagen-containing extracellular matrix. Is expressed in several structures, including alimentary system; connective tissue; eye; nervous system; and reproductive system. Orthologous to human PRELP (proline and arginine rich end leucine rich repeat protein). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Prelp |
| Official Name | proline arginine-rich end leucine-rich repeat [Source:MGI Symbol;Acc:MGI:2151110] |
| Ensembl ID | ENSMUSG00000041577 |
| Bio databases IDs | |
| Aliases | proline arginine-rich end leucine-rich repeat |
| Synonyms | 7330409J17Rik, LOC100363743, MST161, MSTP161, Prolargin, proline and arginine rich end leucine rich repeat protein, proline arginine-rich end leucine-rich repeat, SLRR2A |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Prelp often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- leucine rich domain
- protein phosphatase 1 regulatory subunit 42
- extracellular matrix structural constituent conferring compression resistance
- Leucine rich repeat
- heparin binding domain
- extracellular matrix structural constituent
- Leucine rich repeat N-terminal domain
- Leucine Rich repeats (2 copies)
- basic domain
- heparin binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- rheumatoid arthritis
- ulcerative colitis
- preeclampsia
- osteoarthritis
- squamous-cell carcinoma
- squamous cell cancer
- chronic sinusitis
- endometriosis
- aldosterone producing adrenocortical adenoma
- adenoma formation
role in cell
- expression in
- proliferation
- growth
- morphology
- senescence in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Golgi lumen
- lysosomal compartment
- extracellular matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Prelp gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- skeletal system development
- cellular senescence
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- lysosomal lumen
- extracellular matrix
- extracellular region
- Golgi lumen
Molecular Function
What the gene product does at the molecular level
- extracellular matrix structural constituent conferring compression resistance
- heparin binding
- extracellular matrix structural constituent