Entpd3 Gene Summary [Mouse]
Enables nucleoside diphosphate phosphatase activity and ribonucleoside triphosphate phosphatase activity. Acts upstream of or within nucleoside diphosphate catabolic process and nucleoside triphosphate catabolic process. Located in plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; sensory organ; skeleton; and urinary system. Orthologous to human ENTPD3 (ectonucleoside triphosphate diphosphohydrolase 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Entpd3 |
| Official Name | ectonucleoside triphosphate diphosphohydrolase 3 [Source:MGI Symbol;Acc:MGI:1321386] |
| Ensembl ID | ENSMUSG00000041608 |
| Bio databases IDs | |
| Aliases | ectonucleoside triphosphate diphosphohydrolase 3 |
| Synonyms | CD39 antigen-like 3, CD39L3, ectonucleoside triphosphate diphosphohydrolase 3, HB6, NTPDase-3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Entpd3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- nucleoside-triphosphatase
- nucleoside-diphosphatase
- enzyme
- protein binding
- ASKHA_ATPase-like
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- pruritus
- ulcerative colitis
- androgenic alopecia
- keratocystic odontogenic tumor
- keratocystic odontogenic tumors
regulated by
- cisplatin
- FOXA2
- doxorubicin
- SMARCA4
- 1810019D21Rik
- DMD
- tunicamycin
- Sn12c cells
- methotrexate
- ifosfamide
regulates
- adenosine triphosphate
- nucleoside triphosphate
- proinsulin
- PGAM5
- nucleoside diphosphates
role in cell
- degradation in
- number
- hydrolysis in
- molecular cleavage in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- apical cell surfaces
- basolateral cell surfaces
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Entpd3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- nucleoside diphosphate catabolic process
- nucleoside triphosphate catabolic process
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- apyrase activity
- uridine-diphosphatase activity
- guanosine-diphosphatase activity
- nucleoside-diphosphatase activity
- nucleoside-triphosphatase activity