Stx2 Gene Summary [Mouse]
Enables calcium-dependent protein binding activity. Involved in acrosome reaction. Acts upstream of or within cell differentiation. Located in several cellular components, including cell surface; cell-cell junction; and membrane raft. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; nervous system; and respiratory system. Orthologous to human STX2 (syntaxin 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Stx2 |
| Official Name | syntaxin 2 [Source:MGI Symbol;Acc:MGI:108059] |
| Ensembl ID | ENSMUSG00000029428 |
| Bio databases IDs | |
| Aliases | syntaxin 2 |
| Synonyms | EPIM, Epimorphin, EPM, G1-536-1, repro34, STX2A, STX2B, STX2C, Syn-2, Syntaxin 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Stx2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SNARE binding
- calcium-dependent protein binding
- protein binding
- identical protein binding
- SynN
- cytoplasmic domain
- Mediator complex subunit 28
- SNARE domain
- Helical region found in SNAREs
- transmembrane domain
- Syntaxin
- SNARE motif
- structural molecule
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- venous thromboembolism
- metastasis
- coronary artery disease
- ischemic stroke
- hyperplasia
- tumorigenesis
- colitis
role in cell
- injury
- formation
- proliferation
- differentiation
- response by
- release
- targeting
- abscission in
- cytokinesis
- abscission
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- plasma membrane fraction
- membrane fraction
- intracellular membrane-bounded organelle
- cell surface
- Extracellular Space
- cellular membrane
- Nucleus
- Plasma Membrane
- vesicles
- midbody
- intercellular junctions
- cytosol
- apical cell surfaces
- apical membrane
- basolateral membrane
- alpha granule membranes
- synapse
- vacuolar apical compartments
- cytoplasmic vesicles
- membrane rafts
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Stx2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- acrosome reaction
- signal transduction
- vesicle docking
- synaptic vesicle fusion to presynaptic membrane
- cellular response to oxidative stress
- ectoderm development
- intracellular protein transport
- exocytosis
- organ morphogenesis
Cellular Component
Where in the cell the gene product is active
- extracellular space
- synaptic vesicle
- intracellular membrane-bounded organelle
- SNARE complex
- endomembrane system
- macromolecular complex
- presynaptic active zone membrane
- basolateral plasma membrane
- plasma membrane
- lamellipodium
Molecular Function
What the gene product does at the molecular level
- protein binding
- structural molecule activity
- SNAP receptor activity
- calcium-dependent protein binding
- SNARE binding