Coq5 Gene Summary [Mouse]
Predicted to enable 2-methoxy-6-polyprenyl-1,4-benzoquinol methyltransferase activity. Predicted to be involved in methylation and ubiquinone biosynthetic process. Located in mitochondrion. Is expressed in heart and heart right ventricle. Human ortholog(s) of this gene implicated in primary coenzyme Q10 deficiency 9. Orthologous to human COQ5 (coenzyme Q5, methyltransferase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Coq5 |
| Official Name | coenzyme Q5 methyltransferase [Source:MGI Symbol;Acc:MGI:1098643] |
| Ensembl ID | ENSMUSG00000041733 |
| Bio databases IDs | |
| Aliases | coenzyme Q5 methyltransferase |
| Synonyms | 1810014G04Rik, coenzyme Q5 methyltransferase, coenzyme Q5, methyltransferase, COQ10D9, D5Ertd33e, RGD1310857 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Coq5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquinone biosynthesis methyltransferase
- enzyme
- protein binding
- AdoMet_MTases
- ubiE/COQ5 methyltransferase family
- methyltransferase domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial matrix
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Coq5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ubiquinone biosynthetic process
- methylation
Cellular Component
Where in the cell the gene product is active
- mitochondrial matrix
- macromolecular complex
- extrinsic to mitochondrial inner membrane
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity