Gsk3a Gene Summary [Mouse]
Enables protein serine/threonine kinase activity and signaling receptor binding activity. Involved in several processes, including cell surface receptor signaling pathway; positive regulation of G protein-coupled receptor signaling pathway; and positive regulation of metabolic process. Acts upstream of with a positive effect on autosome genomic imprinting. Acts upstream of or within several processes, including cellular response to lithium ion; positive regulation of protein phosphorylation; and protein phosphorylation. Predicted to be located in microtubule. Predicted to be part of beta-catenin destruction complex. Predicted to be active in axon; cytosol; and nucleus. Is expressed in several structures, including alimentary system; bone; central nervous system; craniofacial suture; and early conceptus. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis. Orthologous to human GSK3A (glycogen synthase kinase 3 alpha). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gsk3a |
| Official Name | glycogen synthase kinase 3 alpha [Source:MGI Symbol;Acc:MGI:2152453] |
| Ensembl ID | ENSMUSG00000057177 |
| Bio databases IDs | |
| Aliases | glycogen synthase kinase 3 alpha |
| Synonyms | 2700086H06RIK, glycogen synthase kinase 3 alpha, glycogen synthase kinase 3 α, Gsk3 alpha, Gsk3-α |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gsk3a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- protein kinase
- protein kinase A binding
- Akt phosphorylation site
- protein kinase binding
- priming phosphorylation binding site
- protein binding
- receptor binding
- Protein kinase domain
- kinase
- Serine/Threonine protein kinases, catalytic domain
- Protein Kinases, catalytic domain
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the Gsk3a gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- 14-3-3-mediated Signaling
- Adrenomedullin signaling pathway
- Apelin Liver Signaling Pathway
- Autophagy
- B Cell Receptor Signaling
- Circadian Rhythm Signaling
- CTLA4 Signaling in Cytotoxic T Lymphocytes
- Docosahexaenoic Acid (DHA) Signaling
- ErbB2-ErbB3 Signaling
- Estrogen Receptor Signaling
- FAK Signaling
- GP6 Signaling Pathway
- HER-2 Signaling in Breast Cancer
- IL-7 Signaling Pathway
- ILK Signaling
- Insulin Receptor Signaling
- Protein Kinase A Signaling
- PTEN Signaling
- Sertoli Cell-Sertoli Cell Junction Signaling
- T Cell Receptor Signaling
- WNT/β-catenin Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- psoriasis
- weight gain
- schizophrenia
- organismal death
- fibrosis
- reperfusion injury
- impaired glucose tolerance
- oligozoospermia
- memory deficits
role in cell
- proliferation
- cell death
- apoptosis
- expression in
- phosphorylation in
- activation in
- molecular cleavage in
- autophagy by
- inhibition in
- signaling in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cellular membrane
- microtubules
- cytosol
- nucleoplasm
- nuclear bodies
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gsk3a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of microtubule cytoskeleton organization
- negative regulation of cell growth involved in cardiac muscle cell development
- insulin receptor signaling pathway
- regulation of systemic arterial blood pressure
- nervous system development
- dopamine receptor signaling pathway
- extrinsic apoptotic signaling pathway
- extrinsic apoptotic signaling pathway in absence of ligand
- positive regulation of heart contraction
- protein phosphorylation
- positive regulation of transcription from RNA polymerase II promoter
- cellular response to insulin stimulus
- viral protein processing
- positive regulation of protein ubiquitination
- Wnt receptor signaling pathway
- negative regulation of type B pancreatic cell development
- regulation of neuron projection development
- negative regulation of TOR signaling cascade
- positive regulation of adrenergic receptor signaling pathway
- cell migration
- positive regulation of peptidyl-serine phosphorylation
- regulation of excitatory postsynaptic membrane potential
- negative regulation of glycogen biosynthetic process
- negative regulation of glucose import
- positive regulation of protein catabolic process
- negative regulation of insulin receptor signaling pathway
- cardiac left ventricle morphogenesis
- negative regulation of canonical Wnt receptor signaling pathway
- negative regulation of UDP-glucose catabolic process
- cellular response to lithium ion
- positive regulation of autophagy
- proteasomal ubiquitin-dependent protein catabolic process
- glycogen metabolic process
- positive regulation of gene expression
- cellular response to glucocorticoid stimulus
- cell differentiation
- positive regulation of peptidyl-threonine phosphorylation
- cellular response to interleukin-3
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process
- peptidyl-threonine phosphorylation
- positive regulation of glycogen (starch) synthase activity
- negative regulation of glycogen (starch) synthase activity
Cellular Component
Where in the cell the gene product is active
- beta-catenin destruction complex
- nucleus
- cytoplasm
- mitochondrion
- cytosol
- neuronal cell body
- axon
Molecular Function
What the gene product does at the molecular level
- tau-protein kinase activity
- ATP binding
- protein binding
- tau protein binding
- protein kinase A catalytic subunit binding
- protein serine/threonine kinase activity
- receptor binding