Pelo Gene Summary [Mouse]
Predicted to enable ribosome binding activity and stalled ribosome sensor activity. Acts upstream of or within several processes, including inner cell mass cell proliferation; mesenchymal to epithelial transition; and positive regulation of BMP signaling pathway. Predicted to be part of Dom34-Hbs1 complex. Predicted to be active in cytosolic ribosome. Is expressed in several structures, including central nervous system; genitourinary system; limb muscle; orbito-sphenoid; and spleen. Orthologous to human PELO (pelota mRNA surveillance and ribosome rescue factor). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pelo |
| Official Name | pelota mRNA surveillance and ribosome rescue factor [Source:MGI Symbol;Acc:MGI:2145154] |
| Ensembl ID | ENSMUSG00000042275 |
| Bio databases IDs | |
| Aliases | pelota mRNA surveillance and ribosome rescue factor |
| Synonyms | CGI-17, Pelota, pelota mRNA surveillance and ribosome rescue factor, PRO1770 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pelo often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- eRF1 domain 3
- mRNA surveillance protein pelota
- eRF1 domain 1
- ribosome binding
- protein binding
- enzyme regulator activity
- peptide chain release factor 1, archaeal and eukaryotic forms
- eRF1 domain 2
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- non-insulin-dependent diabetes mellitus
- growth failure
regulated by
- dexamethasone
- CDKN1A
- methylprednisolone
- GARS1
- sodium arsenite
- megakaryocytes
- gentamicin
- Bacillus anthracis strain Sterne
regulates
role in cell
- migration
- proliferation
- organization
- maintenance
- disassembly
- aneuploidy
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- ribosome
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pelo gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mesenchymal to epithelial transition
- stem cell maintenance
- endoderm development
- ribosome disassembly
- regulation of translation
- cell division
- nuclear-transcribed mRNA catabolic process, non-stop decay
- positive regulation of BMP signaling pathway
- inner cell mass cell proliferation
- RNA surveillance
- nonfunctional rRNA decay
- rescue of stalled ribosome
- chromosome organization
- nuclear-transcribed mRNA catabolic process, no-go decay
Cellular Component
Where in the cell the gene product is active
- cytosolic ribosome
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- ribosome binding