PELO Gene Summary [Human]
This gene encodes a protein which contains a conserved nuclear localization signal. The encoded protein may have a role in spermatogenesis, cell cycle control, and in meiotic cell division. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | PELO |
| Official Name | pelota mRNA surveillance and ribosome rescue factor [Source:HGNC Symbol;Acc:HGNC:8829] |
| Ensembl ID | ENSG00000152684 |
| Bio databases IDs | |
| Aliases | pelota mRNA surveillance and ribosome rescue factor |
| Synonyms | CGI-17, Pelota, pelota mRNA surveillance and ribosome rescue factor, PRO1770 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PELO often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- eRF1 domain 3
- mRNA surveillance protein pelota
- eRF1 domain 1
- ribosome binding
- protein binding
- enzyme regulator activity
- peptide chain release factor 1, archaeal and eukaryotic forms
- eRF1 domain 2
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- non-insulin-dependent diabetes mellitus
- growth failure
regulates
role in cell
- migration
- proliferation
- organization
- maintenance
- disassembly
- aneuploidy
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- ribosome
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PELO gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mesenchymal to epithelial transition
- stem cell maintenance
- endoderm development
- ribosome disassembly
- regulation of translation
- cell division
- nuclear-transcribed mRNA catabolic process, non-stop decay
- positive regulation of BMP signaling pathway
- inner cell mass cell proliferation
- RNA surveillance
- nonfunctional rRNA decay
- rescue of stalled ribosome
- chromosome organization
- nuclear-transcribed mRNA catabolic process, no-go decay
Cellular Component
Where in the cell the gene product is active
- cytosolic ribosome
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- ribosome binding