Pelo

Predicted to enable nucleoside-triphosphatase regulator activity; ribosome binding activity; and stalled ribosome sensor activity. Predicted to be involved in nonfunctional rRNA decay; nuclear-transcribed mRNA catabolic process, no-go decay; and rescue of stalled ribosome. Predicted to act upstream of or within several processes, including inner cell mass cell proliferation; mesenchymal to epithelial transition; and positive regulation of BMP signaling pathway. Predicted to be part of Dom34-Hbs1 complex. Predicted to be active in cytosolic ribosome. Orthologous to human PELO (pelota mRNA surveillance and ribosome rescue factor). [provided by Alliance of Genome Resources, Jul 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pelo often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the rat Pelo gene, providing context for its role in the cell.