Oma1 Gene Summary [Mouse]
Enables metalloendopeptidase activity. Involved in several processes, including diet induced thermogenesis; negative regulation of mitochondrial fusion; and protein processing. Acts upstream of or within cristae formation. Located in mitochondrial inner membrane. Is expressed in alimentary system; cerebral cortex; liver lobe; nose; and submandibular gland primordium. Orthologous to human OMA1 (OMA1 zinc metallopeptidase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Oma1 |
| Official Name | OMA1 zinc metallopeptidase [Source:MGI Symbol;Acc:MGI:1914263] |
| Ensembl ID | ENSMUSG00000035069 |
| Bio databases IDs | |
| Aliases | OMA1 zinc metallopeptidase |
| Synonyms | 2010001O09Rik, DAB1, MPRP-1, OMA1 zinc metallopeptidase, peptidase, RGD1304821, YKR087C, ZMPOMA1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Oma1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Peptidase family M48
- peptidase
- Peptidase_M48_M56
- metalloendopeptidase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
- postmenopausal osteoporosis
- weight gain
- hepatic steatosis
- hepatitis A
- breast cancer
- neuroinflammation
- colorectal adenoma
- colorectal adenoma formation
- restless legs syndrome
role in cell
- apoptosis
- morphology
- molecular cleavage in
- damage in
- formation
- induction in
- fusion
- fragmentation in
- stabilization in
- function
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial membrane
- mitochondrial intermembrane space
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Oma1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cristae formation
- glucose metabolic process
- diet induced thermogenesis
- zymogen activation
- misfolded or incompletely synthesized protein catabolic process
- negative regulation of mitochondrial fusion
- positive regulation of apoptotic process
- lipid metabolic process
- energy homeostasis
- protein autoprocessing
- mitochondrial protein processing
- mitochondrial respiratory chain complex assembly
Cellular Component
Where in the cell the gene product is active
- mitochondrial intermembrane space
- mitochondrial membrane
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- metal ion binding
- lipid binding
- metalloendopeptidase activity