Sgsm3 Gene Summary [Mouse]
Predicted to enable GTPase activator activity and small GTPase binding activity. Involved in positive regulation of protein catabolic process. Located in gap junction. Is expressed in several structures, including central nervous system; ganglia; genitourinary system; lung; and submandibular gland primordium. Orthologous to human SGSM3 (small G protein signaling modulator 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sgsm3 |
| Official Name | small G protein signaling modulator 3 [Source:MGI Symbol;Acc:MGI:1916329] |
| Ensembl ID | ENSMUSG00000042303 |
| Bio databases IDs | |
| Aliases | small G protein signaling modulator 3 |
| Synonyms | 1810012I01RIK, bdif-1, CIP85, MAP, RABGAP5, RABGAPLP, RUSC3, RUTBC3, small G protein signaling modulator 3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sgsm3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Rab-GTPase-TBC domain
- domain involved in Ras-like GTPase signaling
- Domain in Tre-2, BUB2p, and Cdc16p
- enzyme binding
- GTPase activator
- protein binding
- RUN domain
- Src Homology 3 domain superfamily
Pathways
Biological processes and signaling networks where the Sgsm3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cytosol
- gap junctions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sgsm3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of Rab protein signal transduction
- positive regulation of protein catabolic process
- plasma membrane to endosome transport
- regulation of cell cycle
- Rap protein signal transduction
- positive regulation of GTPase activity
Cellular Component
Where in the cell the gene product is active
- gap junction
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- GTPase activator activity
- small GTPase binding