Tsen2 Gene Summary [Mouse]
Predicted to enable tRNA-intron lyase activity. Predicted to be involved in tRNA-type intron splice site recognition and cleavage. Predicted to be located in centrosome; cytosol; and nucleoplasm. Predicted to be part of tRNA-intron endonuclease complex. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 2B. Orthologous to human TSEN2 (tRNA splicing endonuclease subunit 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tsen2 |
| Official Name | tRNA splicing endonuclease subunit 2 [Source:MGI Symbol;Acc:MGI:2141599] |
| Ensembl ID | ENSMUSG00000042389 |
| Bio databases IDs | |
| Aliases | tRNA splicing endonuclease subunit 2 |
| Synonyms | PCH2B, RGD1309946, SEN2L, tRNA splicing endonuclease subunit 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tsen2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- tRNA intron endonuclease, catalytic C-terminal domain
- tRNA-intron endonuclease
- tRNA-intron lyase
- enzyme
- protein binding
- PDDEXK family nucleases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-syndromic congenital pontocerebellar hypoplasia
- systemic lupus erythematosus
- pontocerebellar hypoplasia type 2B
- hemolytic uremic syndrome
- gastric polyp
- hereditary disorder
role in cell
- replication in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- centrosome
- cytosol
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tsen2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- tRNA splicing, via endonucleolytic cleavage and ligation
- mRNA processing
- tRNA-type intron splice site recognition and cleavage
Cellular Component
Where in the cell the gene product is active
- centrosome
- cytosol
- nucleolus
- tRNA-intron endonuclease complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- nucleic acid binding
- protein binding
- lyase activity
- tRNA-intron endonuclease activity