Ror2 Gene Summary [Mouse]
Enables Wnt-protein binding activity; frizzled binding activity; and mitogen-activated protein kinase kinase kinase binding activity. Involved in positive regulation of DNA-templated transcription and positive regulation of canonical Wnt signaling pathway. Acts upstream of or within several processes, including cartilage development; cell surface receptor signaling pathway; and embryonic morphogenesis. Predicted to be located in several cellular components, including cell surface; microtubule; and neuronal cell body. Predicted to be part of receptor complex. Predicted to be active in several cellular components, including axon; glutamatergic synapse; and postsynapse. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and sensory organ. Used to study autosomal recessive Robinow syndrome. Human ortholog(s) of this gene implicated in autosomal recessive Robinow syndrome; brachydactyly type B1; and cleft palate. Orthologous to human ROR2 (receptor tyrosine kinase like orphan receptor 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Ror2 |
| Official Name | receptor tyrosine kinase-like orphan receptor 2 [Source:MGI Symbol;Acc:MGI:1347521] |
| Ensembl ID | ENSMUSG00000021464 |
| Bio databases IDs | |
| Aliases | receptor tyrosine kinase-like orphan receptor 2 |
| Synonyms | BDB, BDB1, LOC101927935, NTRKR2, receptor tyrosine kinase-like orphan receptor 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ror2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- KR
- Wnt-protein binding
- frizzled binding
- Fz domain
- protein-tyrosine kinase
- Protein kinase domain
- proline rich domain
- CRD_domain cysteine-rich domain, also known as Fz (frizzled) domain
- Immunoglobulin like
- intracellular domain
- Tyrosine kinase, catalytic domain
- Immunoglobulin V-set domain
- cysteine rich domain
- coreceptor
- extracellular domain
- Protein kinase (unclassified specificity)
- protein kinase binding
- Protein tyrosine and serine/threonine kinase
- immunoglobulin domain
- Immunoglobulin I-set domain
- Tyrosine autophosphorylation site
- protein binding
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- Protein Kinases, catalytic domain
- transmembrane receptor protein tyrosine kinase
- STP box
- transmembrane domain
- tyrosine kinase domain
- serine threonine rich domain
Pathways
Biological processes and signaling networks where the Ror2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- glaucoma
- COVID-19
- non-insulin-dependent diabetes mellitus
- mechanical hypersensitivity
- brachydactyly type B1
- cutaneous melanoma
- autosomal recessive Robinow syndrome
- breast cancer
- Robinow syndrome
- cutaneous melanoma cancer
phenotypes
- preweaning lethality complete penetrance
- abnormal Meckel's cartilage morphology
- abnormal autopod morphology
- abnormal axial skeleton morphology
- abnormal blood homeostasis
- abnormal bone mineralization
- abnormal cartilage development
- abnormal cartilage morphology
- abnormal caudal vertebrae morphology
- abnormal cochlear hair cell morphology
- abnormal cochlear outer hair cell morphology
- abnormal craniofacial development
- abnormal cranium morphology
- abnormal digit development
- abnormal digit morphology
- abnormal endochondral bone ossification
- abnormal facial morphology
- abnormal femur morphology
- abnormal fibula morphology
- abnormal forelimb stylopod morphology
- abnormal forelimb zeugopod morphology
- abnormal hindgut morphology
- abnormal hindlimb stylopod morphology
- abnormal hindlimb zeugopod morphology
- abnormal humerus morphology
- abnormal intervertebral disk morphology
- abnormal jaw morphology
- abnormal limb development
- abnormal limb morphology
- abnormal long bone epiphyseal plate morphology
- abnormal long bone epiphyseal plate proliferative zone
- abnormal long bone morphology
- abnormal malleus morphology
- abnormal mandible morphology
- abnormal mandibular angle morphology
- abnormal mandibular condyloid process morphology
- abnormal maxilla morphology
- abnormal middle ear ossicle morphology
- abnormal nasal bone morphology
- abnormal nasal capsule morphology
- abnormal organ of Corti morphology
- abnormal phalanx morphology
- abnormal primordial germ cell migration
- abnormal pulmonary alveolus morphology
- abnormal radius morphology
- abnormal reproductive system physiology
- abnormal rib morphology
- abnormal sacral vertebrae morphology
- abnormal seminiferous tubule morphology
- abnormal skeleton development
- abnormal skeleton morphology
- abnormal somite development
- abnormal somite shape
- abnormal somite size
- abnormal tail development
- abnormal tail morphology
- abnormal tegmen tympani morphology
- abnormal thoracic vertebrae morphology
- abnormal tibia morphology
- abnormal ulna morphology
- abnormal vertebrae development
- abnormal vertebrae morphology
- abnormal vertebral column morphology
- brachydactyly
- brachyphalangia
- broad nasal bone
- caudal body truncation
- caudal vertebral fusion
- cleft palate
- cleft secondary palate
- cyanosis
- decreased birth body size
- decreased body length
- decreased body size
- decreased bone trabecula number
- decreased embryo size
- decreased length of long bones
- decreased primordial germ cell number
- decreased testis weight
- decreased total body fat amount
- decreased trabecular bone volume
- decreased width of hypertrophic chondrocyte zone
- delayed bone ossification
- delayed chondrocyte differentiation
- delayed endochondral bone ossification
- entropion
- excessive tearing
- failure of palatal shelf elevation
- genital tubercle hypoplasia
- impaired somite development
- increased cranium width
- increased lean body mass
- increased primordial germ cell apoptosis
- increased width of hypertrophic chondrocyte zone
- kinked tail
- large orbits
- midface hypoplasia
- neonatal lethality complete penetrance
- ocular hypertelorism
- oligozoospermia
- perimembraneous ventricular septal defect
- perinatal lethality
- perinatal lethality complete penetrance
- polydactyly
- reduced male fertility
- respiratory distress
- rib fusion
- sacral vertebral fusion
- short Meckel's cartilage
- short femur
- short fibula
- short humerus
- short limbs
- short lumbar vertebrae
- short mandible
- short metacarpal bones
- short nasal bone
- short radius
- short snout
- short tail
- short tibia
- short ulna
- small caudal vertebrae
- small sacral vertebrae
- small seminiferous tubules
- small tail bud
- transposition of great arteries
- vertebral body hypoplasia
role in cell
- expression in
- quantity
- cell viability
- phosphorylation in
- activation in
- formation
- formation in
- proliferation
- apoptosis
- morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- endocytic vesicle membrane
- cell surface
- postsynaptic region
- cellular membrane
- Endoplasmic Reticulum
- microtubules
- growth cone
- neurites
- perikaryon
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ror2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- astrocyte development
- bone mineralization
- signal transduction
- multicellular organismal development
- transmembrane receptor protein tyrosine kinase signaling pathway
- positive regulation of macrophage differentiation
- male genitalia development
- positive regulation of ERK1 and ERK2 cascade
- Wnt receptor signaling pathway
- positive regulation of kinase activity
- positive regulation of neuron projection development
- positive regulation of synaptic transmission, glutamatergic
- positive regulation of protein kinase B signaling cascade
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- dendrite
- clathrin-coated endocytic vesicle membrane
- receptor complex
- neuronal cell body
- plasma membrane
- cell surface
- microtubule
Molecular Function
What the gene product does at the molecular level
- ATP binding
- coreceptor activity
- protein binding
- transmembrane receptor protein tyrosine kinase activity
- metal ion binding
- mitogen-activated protein kinase kinase kinase binding
- Wnt-protein binding