Clp1 Gene Summary [Mouse]
Predicted to enable ATP-dependent polyribonucleotide 5'-hydroxyl-kinase activity. Involved in cerebellar cortex development. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of tRNA-intron endonuclease complex. Predicted to be active in nucleus. Is expressed in brain; genitourinary system; hemolymphoid system; and liver lobe. Used to study pontocerebellar hypoplasia type 10. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 10. Orthologous to human CLP1 (cleavage factor polyribonucleotide kinase subunit 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Clp1 |
| Official Name | CLP1, cleavage and polyadenylation factor I subunit [Source:MGI Symbol;Acc:MGI:2138968] |
| Ensembl ID | ENSMUSG00000027079 |
| Bio databases IDs | |
| Aliases | CLP1, cleavage and polyadenylation factor I subunit |
| Synonyms | cleavage factor polyribonucleotide kinase subunit 1, CLP1, cleavage and polyadenylation factor I subunit, hClp1, HEAB, RGD1307679 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Clp1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- N-terminal beta-sandwich domain of polyadenylation factor
- Pre-mRNA cleavage complex II protein Clp1
- 50S ribosome-binding GTPase
- ATP binding
- protein binding
- polynucleotide 5'-hydroxyl-kinase
- P-loop containing Nucleoside Triphosphate Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- paralysis
- pathological denervation
- pontocerebellar hypoplasia type 10
- major depression
- alcohol use disorder
- respiratory failure
- non-syndromic congenital pontocerebellar hypoplasia
regulated by
- topotecan
- SCp2 cells
- camptothecin
- MMP3
regulates
- RISC
- CFII
role in cell
- loss
- degeneration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Clp1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- tRNA splicing, via endonucleolytic cleavage and ligation
- mRNA 3'-end processing
- small RNA loading onto RISC
- cerebellar cortex development
Cellular Component
Where in the cell the gene product is active
- nucleus
- mRNA cleavage factor complex
- cytosol
- tRNA-intron endonuclease complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- polynucleotide 5'-hydroxyl-kinase activity
- protein binding
- ATP-dependent polyribonucleotide 5'-hydroxyl-kinase activity
- ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity