Znrf1 Gene Summary [Mouse]
Enables ubiquitin protein ligase activity. Involved in proteasome-mediated ubiquitin-dependent protein catabolic process and protein K48-linked ubiquitination. Predicted to be located in cytosol and endosome. Predicted to be active in cytoplasm; intracellular membrane-bounded organelle; and membrane. Is expressed in several structures, including central nervous system; genitourinary system; and retina nuclear layer. Orthologous to human ZNRF1 (zinc and ring finger 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Znrf1 |
| Official Name | zinc and ring finger 1 [Source:MGI Symbol;Acc:MGI:2177308] |
| Ensembl ID | ENSMUSG00000033545 |
| Bio databases IDs | |
| Aliases | zinc and ring finger 1 |
| Synonyms | B830022L21Rik, FLJ14846, LOC687239, NERVE INJURY GENE 283, NIN283, Rnf42, zinc and ring finger 1, Zrfp1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Znrf1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RING-type zinc-finger
- ubiquitin protein ligase activity
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- ubiquitin-protein transferase activity
- enzyme
- Ring finger domain
- protein binding
- RING-like zinc finger
- RING-H2 zinc finger domain
- Zinc finger, C3HC4 type (RING finger)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- cellular membrane
- endosomes
- cytosol
- endosome-lysosome compartments
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Znrf1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteasomal ubiquitin-dependent protein catabolic process
- protein K48-linked ubiquitination
- positive regulation of toll-like receptor 4 signaling pathway
Cellular Component
Where in the cell the gene product is active
- endosome
- cytoplasm
- intracellular membrane-bounded organelle
- membrane
- cytosol
- synaptic vesicle membrane
- plasma membrane
- lysosome
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- protein binding
- metal ion binding