Kcna10 Gene Summary [Mouse]
Predicted to enable delayed rectifier potassium channel activity. Predicted to be involved in action potential and potassium ion transmembrane transport. Predicted to act upstream of or within potassium ion transport. Predicted to be located in plasma membrane. Predicted to be part of voltage-gated potassium channel complex. Predicted to be active in membrane. Is expressed in several structures, including inner ear and skeletal muscle. Used to study vestibular disease. Orthologous to human KCNA10 (potassium voltage-gated channel subfamily A member 10). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Kcna10 |
| Official Name | potassium voltage-gated channel, shaker-related subfamily, member 10 [Source:MGI Symbol;Acc:MGI:3037820] |
| Ensembl ID | ENSMUSG00000042861 |
| Bio databases IDs | |
| Aliases | potassium voltage-gated channel, shaker-related subfamily, member 10 |
| Synonyms | Gm1962, Kcn1, KCNA8, Kv1.8, potassium voltage-gated channel, shaker-related subfamily, member 10, potassium voltage-gated channel subfamily A member 10 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Kcna10 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- voltage-gated potassium channel
- Ion transport protein
- Broad-Complex, Tramtrack and Bric a brac
- BTB_POZ
- protein binding
- intracellular cyclic nucleotide activated cation channel
- ion channel
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- multiple sclerosis
- relapsing-remitting multiple sclerosis
- secondary progressive multiple sclerosis
- primary progressive multiple sclerosis
- nerve injury
- nonarteritic ischemic optic neuropathy
regulated by
- dalfampridine
regulates
- K+
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Kcna10 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- potassium ion transport
- potassium ion transmembrane transport
- protein homooligomerization
- regulation of action potential
Cellular Component
Where in the cell the gene product is active
- voltage-gated potassium channel complex
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- voltage-gated potassium channel activity
- protein binding
- delayed rectifier potassium channel activity
- intracellular cyclic nucleotide activated cation channel activity