Ckap4 Gene Summary [Mouse]
Located in endoplasmic reticulum. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; nervous system; and skeletal muscle tissue. Orthologous to human CKAP4 (cytoskeleton associated protein 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ckap4 |
| Official Name | cytoskeleton-associated protein 4 [Source:MGI Symbol;Acc:MGI:2444926] |
| Ensembl ID | ENSMUSG00000046841 |
| Bio databases IDs | |
| Aliases | cytoskeleton-associated protein 4 |
| Synonyms | 5630400A09RIK, CLIMP-63, cytoskeleton-associated protein 4, ERGIC-63, Image:5322388, LOC728680, P63, VS38C |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ckap4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- ischemic stroke
- septic shock
role in cell
- expression in
- activation in
- sphere formation by
- binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- cell surface
- cellular membrane
- Nucleus
- Plasma Membrane
- Endoplasmic Reticulum
- Mitochondria
- secretory granule membrane
- lipid droplets
- specific granule membrane
- endoplasmic reticulum lumen
- lysosome membrane
- nuclear speckles
- alveolar epithelial lamellar bodies
- rough endoplasmatic reticulum
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ckap4 gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- rough endoplasmic reticulum
- endoplasmic reticulum
- lamellar body
- plasma membrane
- endoplasmic reticulum membrane
- lipid particle
- endoplasmic reticulum lumen
- extracellular vesicular exosome
- perinuclear region of cytoplasm
- cytoskeleton
- membrane
- azurophil granule membrane
- specific granule membrane
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding