Dolk Gene Summary [Mouse]
Predicted to enable dolichol kinase activity. Predicted to be involved in dolichol phosphate mannose biosynthetic process; dolichyl monophosphate biosynthetic process; and protein glycosylation. Predicted to be active in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Im. Orthologous to human DOLK (dolichol kinase). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dolk |
| Official Name | dolichol kinase [Source:MGI Symbol;Acc:MGI:2677836] |
| Ensembl ID | ENSMUSG00000075419 |
| Bio databases IDs | |
| Aliases | dolichol kinase |
| Synonyms | CDG1M, DK, DK1, dolichol kinase, LOC227697, mKIAA1094, SEC59, TMEM15 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dolk often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- dolichol kinase
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- congenital disorder of glycosylation type 1m
- cervical small cell carcinoma
- extrapulmonary small cell cancer
- epithelial uterine cancer
- cervical cancer
- hyperalgesia
regulated by
- GABA
- G protein alpha
regulates
- dolichol monophosphate
- dolichol 20
- dolichyl diphosphate
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dolk gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- dolichyl monophosphate biosynthetic process
- dolichyl diphosphate biosynthetic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- dolichol kinase activity