Tmbim6 Gene Summary [Mouse]
Enables endoribonuclease inhibitor activity and enzyme binding activity. Involved in cellular response to unfolded protein; negative regulation of macromolecule biosynthetic process; and response to endoplasmic reticulum stress. Acts upstream of or within endoplasmic reticulum calcium ion homeostasis; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; and neuron intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress. Predicted to be located in endoplasmic reticulum and mitochondrial membrane. Predicted to be active in endoplasmic reticulum membrane. Is expressed in head and retina. Orthologous to human TMBIM6 (transmembrane BAX inhibitor motif containing 6). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tmbim6 |
| Official Name | transmembrane BAX inhibitor motif containing 6 [Source:MGI Symbol;Acc:MGI:99682] |
| Ensembl ID | ENSMUSG00000023010 |
| Bio databases IDs | |
| Aliases | transmembrane BAX inhibitor motif containing 6 |
| Synonyms | 5031406P05Rik, Ab1-011, Ac1-149, BAXI1, BI-1, Cc1-27, TEGT, transmembrane BAX inhibitor motif containing 6 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tmbim6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ribonuclease inhibitor
- ubiquitin protein ligase binding
- Inhibitor of apoptosis-promoting Bax1
- BAX inhibitor (BI)-1/YccA-like protein family
- enzyme binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- diabetes mellitus
- obesity
- lung metastasis
- androgenic alopecia
role in cell
- expression in
- apoptosis
- proliferation
- accumulation in
- activation in
- production in
- cell death
- migration
- quantity
- consumption in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- perinuclear region
- cellular membrane
- Plasma Membrane
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
- mitochondrial membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tmbim6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of apoptotic process
- autophagy
- negative regulation of immunoglobulin production
- negative regulation of calcium ion transport into cytosol
- negative regulation of endoribonuclease activity
- cellular response to unfolded protein
- negative regulation of RNA splicing
- endoplasmic reticulum calcium ion homeostasis
- negative regulation of protein binding
- negative regulation of apoptotic signaling pathway
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- nucleus
- mitochondrial membrane
- cytoplasm
- membrane
- endoplasmic reticulum
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- ubiquitin protein ligase binding
- endoribonuclease inhibitor activity
- enzyme binding