Greb1l Gene Summary [Mouse]
Acts upstream of or within several processes, including heart development; kidney development; and reproductive structure development. Predicted to be located in membrane. Is expressed in several structures, including brain; liver; tail unsegmented mesenchyme; thymus; and urinary system. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 80 and renal agenesis. Orthologous to human GREB1L (GREB1 like retinoic acid receptor coactivator). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Greb1l |
| Official Name | growth regulation by estrogen in breast cancer-like [Source:MGI Symbol;Acc:MGI:3576497] |
| Ensembl ID | ENSMUSG00000042942 |
| Bio databases IDs | |
| Aliases | growth regulation by estrogen in breast cancer-like |
| Synonyms | C18orf6, DFNA80, GREB1 like retinoic acid receptor coactivator, growth regulation by estrogen in breast cancer-like, KIAA1772, mKIAA4095, RGD1562371, RHDA3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Greb1l often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GREB1 N-terminal region
- GREB1 C-terminal region
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulated by
disease
- renal hypodysplasia/aplasia type 3
- aortic valve calcification
- autosomal dominant deafness type 80
- Rokitansky-Küster-Hauser syndrome
- congenital anomalies of kidney and urinary tract
- renal agenesis or hypodysplasia
- inner ear malformation
role in cell
- differentiation
- biogenesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Greb1l gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- metanephros development
- multicellular organismal development
- kidney development
- male genitalia development
- branching involved in ureteric bud morphogenesis
- mesonephric duct development
- uterus development
- cardiac ventricle development
- paramesonephric duct development
Cellular Component
Where in the cell the gene product is active
- membrane