Egflam Gene Summary [Mouse]
Enables glycosaminoglycan binding activity. Acts upstream of or within extracellular matrix organization and positive regulation of cell-substrate adhesion. Located in basement membrane and interstitial matrix. Is active in photoreceptor ribbon synapse. Is expressed in hair follicle and rib. Orthologous to human EGFLAM (EGF like, fibronectin type III and laminin G domains). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Egflam |
| Official Name | EGF-like, fibronectin type III and laminin G domains [Source:MGI Symbol;Acc:MGI:2146149] |
| Ensembl ID | ENSMUSG00000042961 |
| Bio databases IDs | |
| Aliases | EGF-like, fibronectin type III and laminin G domains |
| Synonyms | 5930412K08, AGRINL, AGRNL, EGF-like, fibronectin type III and laminin G domains, FLJ39155, PIKA, Pikachurin, RGD1306592 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Egflam often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- laminin-like globular domain
- LamG
- FN3
- Purple acid Phosphatase, N-terminal domain
- protein binding
- Fibronectin type 3 domain
- glycosaminoglycan binding
- laminin G domain
- EGF_CA
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cell surface
- extracellular matrix
- ribbon synapse
- basement membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Egflam gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- extracellular matrix organization
- positive regulation of cell-substrate adhesion
Cellular Component
Where in the cell the gene product is active
- basement membrane
- synaptic cleft
- interstitial matrix
- presynaptic active zone
- cell projection
Molecular Function
What the gene product does at the molecular level
- protein binding
- glycosaminoglycan binding
- calcium ion binding