Psmb11 Gene Summary [Mouse]
Predicted to enable endopeptidase activity. Acts upstream of or within CD8-positive, alpha-beta T cell differentiation and T cell differentiation in thymus. Part of proteasome core complex. Is expressed in thymus and thymus cortex epithelium. Orthologous to human PSMB11 (proteasome subunit beta 11). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Psmb11 |
| Official Name | proteasome (prosome, macropain) subunit, beta type, 11 [Source:MGI Symbol;Acc:MGI:1921152] |
| Ensembl ID | ENSMUSG00000072423 |
| Bio databases IDs | |
| Aliases | proteasome (prosome, macropain) subunit, beta type, 11 |
| Synonyms | 5830406J20Rik, BETA5T, proteasome (prosome, macropain) subunit, beta type, 11, proteasome (prosome, macropain) subunit, β type, 11, proteasome subunit beta 11, proteasome subunit β 11, RGD1308773 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Psmb11 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ntn_hydrolase
- peptidase
- protein binding
- Proteasome subunit
Pathways
Biological processes and signaling networks where the Psmb11 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Psmb11 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteasomal ubiquitin-dependent protein catabolic process
- T cell differentiation in thymus
- CD8-positive, alpha-beta T cell differentiation
- proteolysis
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
- proteasome core complex, beta-subunit complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- endopeptidase activity
- threonine-type endopeptidase activity
- peptidase activity